Mosquito Shield - Transfluthrin Spatial Repellents Against Malaria-Transmitting Anopheles: Systematic Review and Meta-Analysis
Keywords:
Mosquito Shield, Transfluthrin, Spatial Repellent, Anopheles, MalariaAbstract
Background: A major worldwide health concern, mosquito-borne illnesses primarily affect tropical areas that sustain the mosquito life cycle. In tropical and subtropical regions, vulnerable populations are disproportionately affected by malaria, one of the most well-known mosquito-borne diseases. The WHO African Region is the region with the largest incidence of malaria. Despite the significant success of conventional vector control techniques like indoor residual spraying (IRS) and insecticide-treated nets (ITNs), protection gaps still exist, calling for innovative approaches. This study analyzes the effectiveness of transfluthrin as an innovative spatial repellent that operates without electricity or fire to prevent human-Anopheles mosquito contact.
Methods: A systematic review and meta-analysis assessed Mosquito Shield™ (transfluthrin-based spatial repellent) for reducing malaria vector exposure. Literature from 2019–2024 was searched in databases including Medline and PubMed using terms like “Spatial Repellent” and “Transfluthrin.” Eligible randomized controlled trials in malaria-endemic areas were analyzed for outcomes on Human Landing Catch (HLC), Incidence Rate Ratio (IRR), and Protective Efficacy (PE). Quality appraisal was conducted using Rob 2.0.
Results: Two studies met the inclusion criteria, showing that Mosquito Shield™ significantly reduced mosquito landings compared to placebo, with PE ranging from 34.2% to 70%. The pooled analysis confirmed a statistically significant reduction in mosquito exposure, though high heterogeneity suggests variations in effectiveness by region and mosquito species.
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Copyright (c) 2025 Dinda Puspha Nurhanifah, Dian Andriani Ratna Dewi, Anggie Hernita Azzura, Hanum Zahra Faras Fadhilah, Fitrawan Alfiansyah, Anastasia Refina Renate, Prihati Pujowaskito (Author)
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